neurobiologic basis of alcohol dependence

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پیمان حسنی ابهریان

پزشک متخصص در علوم اعصاب شناختی، پژوهشگر و درمانگر اعتیاد

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Neurobiology of Alcohol Dependence

Alcoholism is a debilitating disorder for the individual and very costly for society. A major goal of alcohol research is to understand the neural underpinnings associated with the transition from alcohol use to alcohol dependence. Positive reinforcement is important in the early stages of alcohol use and abuse. Negative reinforcement can be important early in alcohol use by people self-medicat...

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Genetics of alcohol dependence.

Twin, family, and adoption studies have consistently shown that genetic factors play an important role in the pathogenesis of alcohol dependence. Numerous studies have aimed to identify genes that contribute to susceptibility to alcohol dependence. Whole-genome linkage studies have identified several chromosomal regions that are linked with alcohol dependence. Association studies have also iden...

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Acamprosate for alcohol dependence.

BACKGROUND Alcohol dependence is among the main leading health risk factors in most developed and developing countries. Therapeutic success of psychosocial programs for relapse prevention is moderate, but could potentially be increased by an adjuvant treatment with the glutamate antagonist acamprosate. OBJECTIVES To determine the effectiveness and tolerability of acamprosate in comparison to ...

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Pharmacotherapy for alcohol dependence.

Alcoholism is a major public health problem that is detrimental to the affected individuals as well as to society as a whole. It has been popular belief that alcohol dependence can be controlled through will power, skill building, and support. Therefore, psychosocial therapies have historically been the most utilized treatments for alcohol use disorders.(1).

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Drug and Alcohol Dependence

BACKGROUND: Alcoholism is characterized by impaired decision-making (i.e., choosing intoxication in the face of mounting negative consequences). This impairment may involve a reduced brain response to the negative consequences of behavior, which supports an inclination to engage in risky behaviors. The feedback error-related negativity (F-ERN) is hypothesized to reflect the valence attached to ...

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Drug and Alcohol Dependence

Background: Cocaine use, abuse and dependence remains a pressing public health problem. Based on its mechanism of action, varenicline, an alpha4beta2 partial agonist seemed to be a likely candidate for treating cocaine dependence. Methods: Cocaine dependent participants (n = 37) were enrolled in a 9-week double-blind placebo controlled clinical trial. Varenicline was titrated up to a target dos...

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عنوان ژورنال:
فصلنامه طب اعتیاد

جلد ۱، شماره ۲، صفحات ۱۳-۱۵

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